In the constantly changing universe of longevity science and biohacking, there are few figures who inspire as much fascination—and debate—as Bryan Johnson . The 46-year-old tech mogul, most famous for his multimillion-dollar crusade to reverse biological aging, has again caught public attention. This time, by having performed a procedure that sounds more like science fiction than science reality: a full-body plasma replacement .
In a recent Instagram post, Johnson unveiled matter-of-factly, "I drained all of the plasma from my body," saying his doctor described it as "the cleanest she's ever seen." To most, such an extreme procedure would be seen as outrageous, even perilous. For Johnson, though, it's merely another step on his individual mission to resist the aging process.
Bryan Johnson drains all plasma from his body
This is not Johnson's initial plasma manipulation experiment. Previously, in a highly publicized attempt, he received plasma infusions from his adolescent son as part of what became referred to as the "blood boy" procedure under the theory that young blood could revitalize aged tissue—a theory based on disputed animal research.
His most recent project, which he is now calling "V2," is an even more extreme iteration of that idea. Rather than just being infused with donor plasma, Johnson had all his plasma taken out and replaced by albumin, the main protein in plasma that serves to control blood volume and transport vital substances throughout the body.
As Johnson describes it, the objective of this process is a sort of biological do-over. He asserts that today's body is not able to efficiently get rid of waste and toxins because of lifestyle and environmental choices. By not keeping any of his plasma, he wants to wipe the biochemical clean slate and start over.
Science behind plasma replacement
Although Johnson's plasma replacement therapy is undoubtedly dramatic, its scientific merit is questionable. Transfusions of albumin are medically employed in hospitals to treat certain illnesses such as liver failure or shock, but complete plasma replacement in a healthy subject is very rare and unexplored territory.
Johnson has said that his team is tracking a broad range of biomarkers both before and after the procedure to assess its possible impact on longevity, inflammation, and cellular health. Without peer-reviewed data or clinical trials, though, it's impossible to make firm conclusions.
In spite of this, Johnson reports the experience as being dull. "Nothing, really," he said he felt afterwards. "I felt the same, went to bed, slept the same." Whether this indicates that the treatment did not have any effect—or whether subtleties will manifest themselves in time—is still uncertain.
Bryan Johnson’s experiments spark mixed reactions online
As with most of Johnson's experiments, public reaction has varied from wonder to mockery. Social media users did not hesitate, with one commenting, "Bro is giving so much free data and results," while another recognized, "If people could keep from getting threatened by the harshness of his actions, they'd really see the potential for value his findings could have towards global longevity."
Others were more cynical, comparing his detailed biohacking regimens with less complicated, time-proven methods of aging. One reader posted a poignant remark, "My grandmother lived to 100. She liked life, stayed active, and looked great—all without having her blood drained."
However, there is the feeling that—at least controversially—Johnson's work adds worthwhile data to the overall discussion of aging and longevity. His openness to testing himself provides insight into what the future of preventative medicine and personal optimization will be like.
Johnson’s experiments blend science with spectacle, causing debate
Bryan Johnson's experiments remain on the tightrope between medical progress and contemporary performance art. Critics point out that his techniques are expensive, out-of-reach, and maybe even irresponsible. Supporters reply that all science leaps start with experimentation that pushes the boundaries.
What is clear is that Johnson's fundamental purpose speaks to a universal human aspiration: to prolong life, augment vitality, and put off the inexorable decay of age. His odyssey poses deeper questions regarding the morality of self-experimentation, the availability of anti-aging technology, and the thin dividing line between ingenuity and mania.
Also Read | Pope Leo XIV shares his first social media post as pontiff and deletes all his personal accounts
In a recent Instagram post, Johnson unveiled matter-of-factly, "I drained all of the plasma from my body," saying his doctor described it as "the cleanest she's ever seen." To most, such an extreme procedure would be seen as outrageous, even perilous. For Johnson, though, it's merely another step on his individual mission to resist the aging process.
Bryan Johnson drains all plasma from his body
This is not Johnson's initial plasma manipulation experiment. Previously, in a highly publicized attempt, he received plasma infusions from his adolescent son as part of what became referred to as the "blood boy" procedure under the theory that young blood could revitalize aged tissue—a theory based on disputed animal research.
His most recent project, which he is now calling "V2," is an even more extreme iteration of that idea. Rather than just being infused with donor plasma, Johnson had all his plasma taken out and replaced by albumin, the main protein in plasma that serves to control blood volume and transport vital substances throughout the body.
https://www.instagram.com/reel/DJnTfKLS5bi/ https://www.instagram.com/reel/DJnTfKLS5bi/
As Johnson describes it, the objective of this process is a sort of biological do-over. He asserts that today's body is not able to efficiently get rid of waste and toxins because of lifestyle and environmental choices. By not keeping any of his plasma, he wants to wipe the biochemical clean slate and start over.
Science behind plasma replacement
Although Johnson's plasma replacement therapy is undoubtedly dramatic, its scientific merit is questionable. Transfusions of albumin are medically employed in hospitals to treat certain illnesses such as liver failure or shock, but complete plasma replacement in a healthy subject is very rare and unexplored territory.
Johnson has said that his team is tracking a broad range of biomarkers both before and after the procedure to assess its possible impact on longevity, inflammation, and cellular health. Without peer-reviewed data or clinical trials, though, it's impossible to make firm conclusions.
In spite of this, Johnson reports the experience as being dull. "Nothing, really," he said he felt afterwards. "I felt the same, went to bed, slept the same." Whether this indicates that the treatment did not have any effect—or whether subtleties will manifest themselves in time—is still uncertain.
Bryan Johnson’s experiments spark mixed reactions online
As with most of Johnson's experiments, public reaction has varied from wonder to mockery. Social media users did not hesitate, with one commenting, "Bro is giving so much free data and results," while another recognized, "If people could keep from getting threatened by the harshness of his actions, they'd really see the potential for value his findings could have towards global longevity."
Others were more cynical, comparing his detailed biohacking regimens with less complicated, time-proven methods of aging. One reader posted a poignant remark, "My grandmother lived to 100. She liked life, stayed active, and looked great—all without having her blood drained."
However, there is the feeling that—at least controversially—Johnson's work adds worthwhile data to the overall discussion of aging and longevity. His openness to testing himself provides insight into what the future of preventative medicine and personal optimization will be like.
Johnson’s experiments blend science with spectacle, causing debate
Bryan Johnson's experiments remain on the tightrope between medical progress and contemporary performance art. Critics point out that his techniques are expensive, out-of-reach, and maybe even irresponsible. Supporters reply that all science leaps start with experimentation that pushes the boundaries.
What is clear is that Johnson's fundamental purpose speaks to a universal human aspiration: to prolong life, augment vitality, and put off the inexorable decay of age. His odyssey poses deeper questions regarding the morality of self-experimentation, the availability of anti-aging technology, and the thin dividing line between ingenuity and mania.
Also Read | Pope Leo XIV shares his first social media post as pontiff and deletes all his personal accounts
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